Preliminary fluorescence study in vivo on the distribution of trisulfonated aluminum phthalocyanine in tumor-bearing mice

Hong-Yu Yu; Fa-Pu Chen; Wei Zhou; Chun-Li Su; Zhi-Chang Yang; Jian-Zhong Bao

doi:10.1117/12.182083

5 August 1994 Preliminary fluorescence study in vivo on the distribution of trisulfonated aluminum phthalocyanine in tumor-bearing mice

Hong-Yu Yu, Fa-Pu Chen, Wei Zhou, Chun-Li Su, Zhi-Chang Yang, Jian-Zhong Bao

Author Affiliations +

Proceedings Volume 2321, Second International Conference on Optoelectronic Science and Engineering '94; (1994) https://doi.org/10.1117/12.182083
Event: Optoelectronic Science and Engineering '94: International Conference, 1994, Beijing, China

Abstract

Phthalocyanines (PC), e.g., trisulfonated aluminum phthalocyanine (AlS₃PC), had recently been considered as an efficacious photosensitizer used in photodynamic therapy (PDT) of tumor. Moreover, it might have potential usage in tumor detection due to its high fluorescence quantum yields (0.52, much higher than that of HPD). It is significant to study the fluorescence distribution of AlS₃PC for tumor PDT and tumor detection. In vivo fluorescence measurement on mice bearing S₁₈₀ fibrosarcoma, through the using of He- Ne laser excitement, showed that AlS₃PC (>= 96%, synthesized and purified by our group) can selectively retain in S₁₈₀ fibrosarcoma and the maximum ratio of the relative fluorescence in tumor area to that in nomal area 24 - 48 h after AlS₃PC injection (i.p.) is about 2.9/1.

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Hong-Yu Yu, Fa-Pu Chen, Wei Zhou, Chun-Li Su, Zhi-Chang Yang, and Jian-Zhong Bao "Preliminary fluorescence study in vivo on the distribution of trisulfonated aluminum phthalocyanine in tumor-bearing mice", Proc. SPIE 2321, Second International Conference on Optoelectronic Science and Engineering '94, (5 August 1994); https://doi.org/10.1117/12.182083

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