5 August 1994 Preliminary fluorescence study in vivo on the distribution of trisulfonated aluminum phthalocyanine in tumor-bearing mice
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Proceedings Volume 2321, Second International Conference on Optoelectronic Science and Engineering '94; (1994) https://doi.org/10.1117/12.182083
Event: Optoelectronic Science and Engineering '94: International Conference, 1994, Beijing, China
Abstract
Phthalocyanines (PC), e.g., trisulfonated aluminum phthalocyanine (AlS3PC), had recently been considered as an efficacious photosensitizer used in photodynamic therapy (PDT) of tumor. Moreover, it might have potential usage in tumor detection due to its high fluorescence quantum yields (0.52, much higher than that of HPD). It is significant to study the fluorescence distribution of AlS3PC for tumor PDT and tumor detection. In vivo fluorescence measurement on mice bearing S180 fibrosarcoma, through the using of He- Ne laser excitement, showed that AlS3PC (>= 96%, synthesized and purified by our group) can selectively retain in S180 fibrosarcoma and the maximum ratio of the relative fluorescence in tumor area to that in nomal area 24 - 48 h after AlS3PC injection (i.p.) is about 2.9/1.
© (1994) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Hong-Yu Yu, Hong-Yu Yu, Fa-Pu Chen, Fa-Pu Chen, Wei Zhou, Wei Zhou, Chun-Li Su, Chun-Li Su, Zhi-Chang Yang, Zhi-Chang Yang, Jian-Zhong Bao, Jian-Zhong Bao, } "Preliminary fluorescence study in vivo on the distribution of trisulfonated aluminum phthalocyanine in tumor-bearing mice", Proc. SPIE 2321, Second International Conference on Optoelectronic Science and Engineering '94, (5 August 1994); doi: 10.1117/12.182083; https://doi.org/10.1117/12.182083
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