New distributors for homogeneous and monitorable light delivery in photodynamic therapy

Jerome C. Mizeret; P. Thielen; Jean-Francois Theumann; Roland Bays; Georges A. Wagnieres; Jean-Francois Savary; Philippe Monnier; Hubert van den Bergh

doi:10.1117/12.199228

18 January 1995 New distributors for homogeneous and monitorable light delivery in photodynamic therapy

Jerome C. Mizeret, P. Thielen, Jean-Francois Theumann, Roland Bays, Georges A. Wagnieres, Jean-Francois Savary, Philippe Monnier, Hubert van den Bergh

Author Affiliations +

Proceedings Volume 2323, Laser Interaction with Hard and Soft Tissue II; (1995) https://doi.org/10.1117/12.199228
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

Novel light distributors for interstitial and esophageal photodynamic therapy are presented. A cylindrical light diffuser has been developed mainly for medical applications like interstitial photodynamic therapy, treatment of the bronchi and arterisclerosis. It can be made with a diameter as small as 1 mm or even less. For interstitial therapy, it can be introduced via a hypodermic needle. The main property of this light diffuser is the homogeneity of the light intensity emitted along its whole length which can be 100 mm or more, as well as its excellent radial homogeneity (360 degree(s)) and flexibility. Furthermore, its optical properties are hardly dependent on wavelength used for treatment (500 - 700 nm). Light distributors for esophageal treatment with homogeneity better than +/- 10% have been built and successfully used clinically. A measuring optical fiber allows the control of the dosimetry during the irradiation. Some other properties like the photosensitizer uptake in the tissue or the photobleaching can also be measured in situ and in real time during the treatment.

Citation Download Citation

Jerome C. Mizeret, P. Thielen, Jean-Francois Theumann, Roland Bays, Georges A. Wagnieres, Jean-Francois Savary, Philippe Monnier, and Hubert van den Bergh "New distributors for homogeneous and monitorable light delivery in photodynamic therapy", Proc. SPIE 2323, Laser Interaction with Hard and Soft Tissue II, (18 January 1995); https://doi.org/10.1117/12.199228

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