Absorption spectra of photosensitizers detected in vivo in tumor bearing mice

Rinaldo Cubeddu; Gianfranco L. Canti; Antonio Pifferi; Paola Taroni; Gianluca Valentini

doi:10.1117/12.198707

4 January 1995 Absorption spectra of photosensitizers detected in vivo in tumor bearing mice

Rinaldo Cubeddu, Gianfranco L. Canti, Antonio Pifferi, Paola Taroni, Gianluca Valentini

Proceedings Volume 2324, Optical Biopsy and Fluorescence Spectroscopy and Imaging; (1995) https://doi.org/10.1117/12.198707
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

The absorption spectrum of disulphonated Aluminum Phthalocyanine (AlS₂Pc) was measured in vivo in a murine tumor model by time-resolved reflectance (TRR). Mice bearing the L1210 leukemia were administered intraperitoneally 2.5 mg/kg body weight of AlS₂Pc. Reflectance measurements were performed in the 650-695 nm range before and 4 h after the drug administration. The absorption coefficient at each wavelength was obtained by fitting the experimental curve using the diffusion equation. The spectrum of the photosensitizer was obtained as a difference between the absorption of treated and untreated mice. The absorption spectrum of AlS₂Pc was peaked at 685 nm, showing a red-shift of approximately 15 nm with respect to the spectrum in aqueous solution.

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Rinaldo Cubeddu, Gianfranco L. Canti, Antonio Pifferi, Paola Taroni, and Gianluca Valentini "Absorption spectra of photosensitizers detected in vivo in tumor bearing mice", Proc. SPIE 2324, Optical Biopsy and Fluorescence Spectroscopy and Imaging, (4 January 1995); https://doi.org/10.1117/12.198707

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KEYWORDS

Absorption

In vivo imaging

Tumors

Reflectivity

Tissue optics

Photodynamic therapy

Aluminum

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