Changes in muscle tissue oxygenation assessed by near-infrared spectroscopy (NIRS)

Benoit Vallet; Jacques Mangalaboyi; Patrick Menager; Scott E. Curtis; Claude Chopin; Serge R. Mordon

doi:10.1117/12.198734

4 January 1995 Changes in muscle tissue oxygenation assessed by near-infrared spectroscopy (NIRS)

Benoit Vallet, Jacques Mangalaboyi, Patrick Menager, Scott E. Curtis, Claude Chopin, Serge R. Mordon

Proceedings Volume 2324, Optical Biopsy and Fluorescence Spectroscopy and Imaging; (1995) https://doi.org/10.1117/12.198734
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

We examined the relation between cytochrome aa3 (cyt) oxidation level, oxygen delivery (QO2) and oxygen uptake (VO2) during progressive hindlimb ischemia in pigs. The right hindlimb of 6 anesthetized- ventilated pigs was subjected to progressive ischemia over 100 min by 10 stepwise decreases in pump-controlled blood flow (Q). Hindlimb QO2 was Q x arterial content and VO2 was Q x arteriovenous difference. Cyt oxidation level was measured by multiple wavelength NIRS (Hamamatsu). Measurements were done very 9 min after each change of Q. O2 extraction (ER)2) was determined as VO2/QO2. Critical values for both VO2 and cyt oxidation level as a function of QO2 were determined in each animal and compared by t-test. As QO2 was progressively lowered, VO2 remained constant (3.5 +/- 0.1 ml/min per kg) until QO2 reached a critical value of 5.4 +/- 0.4 ml/min per kg, not statistically different than the QO2 (5.9 +/- 0.4 ml/min per kg) critical for maintaining cyt oxidation level. Critical ERO2 determined using the QO2-VO2 relation (0.60 +/- 0.09) and by the QO2-cyt oxidation relation (0.57 +/- 0.03) were also not significantly different. At the lowest QO2, VO2 was 1.0 ml/min per kg and cyt oxidation level was -7 (mu) M. NIRS appears capable of accurately and noninvasively describing the O2 supply dependency relationship during local ischemic hypoxia.

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Benoit Vallet, Jacques Mangalaboyi, Patrick Menager, Scott E. Curtis, Claude Chopin, and Serge R. Mordon "Changes in muscle tissue oxygenation assessed by near-infrared spectroscopy (NIRS)", Proc. SPIE 2324, Optical Biopsy and Fluorescence Spectroscopy and Imaging, (4 January 1995); https://doi.org/10.1117/12.198734

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KEYWORDS

Oxidation

Near infrared spectroscopy

Oxygen

Tissues

Blood circulation

Hypoxia

Tissue optics

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