Active immunotherapy of Walker-256 carcinosarcoma by tumor-infiltrating lymphocytes associated with photodynamic therapy

Vasile F. Dima; Virgil V. Vasiliu; Dezideriu Laky; Paul Ionescu; Stefan V. Dima

doi:10.1117/12.199148

12 January 1995 Active immunotherapy of Walker-256 carcinosarcoma by tumor-infiltrating lymphocytes associated with photodynamic therapy

Vasile F. Dima, Virgil V. Vasiliu, Dezideriu Laky, Paul Ionescu, Stefan V. Dima

Author Affiliations +

Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199148
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

Experiments were performed on five batches of Wistar inbred rats with Walker-256 carcinosarcoma receiving as sole treatment photodynamic therapy (PDT), tumor-infiltrating lymphocytes (TIL), or associated therapy (PDT + TIL - A; PDT + TIL - B). The control batch (HBSS) consisted of animals with untreated Walker-256 tumors. The results were as follows: the sole treatment (PDT, TIL) gave survival rates between 41.4 and 52.9%, the cure rates ranging from 13.8 to 38.2%. The `combined' therapy in multiple doses increased significantly (92.8%) the survival rate of tumor bearing rats as well as the highest incidence of complete tumor regression (82.1%). Cell-mediated immunity test values in batches III and IV exposed to multiple doses of PDT + TIL showed higher values as compared to the values noticed in batches I - II and the control batch V, performed at 10 and 21 days post-treatment. Summing up, this work demonstrates that `combined' photodynamic therapy with immunotherapy with TIL stimulates cell-mediated antitumoral activity, increases survival rates, and reduces incidence of Walker-256 carcinosarcoma in the rat model.

Citation Download Citation

Vasile F. Dima, Virgil V. Vasiliu, Dezideriu Laky, Paul Ionescu, and Stefan V. Dima "Active immunotherapy of Walker-256 carcinosarcoma by tumor-infiltrating lymphocytes associated with photodynamic therapy", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199148

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