Carrier systems in PDT: on the way to novel antitumor drugs

Joerg G. Moser; Anja Ruebner-Heuermann; Peter Oehr; Hugo Scheer; Anja Vervoorts; Sonja Andrees

doi:10.1117/12.199131

12 January 1995 Carrier systems in PDT: on the way to novel antitumor drugs

Joerg G. Moser, Anja Ruebner-Heuermann, Peter Oehr, Hugo Scheer, Anja Vervoorts, Sonja Andrees

Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199131
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

A novel mode to apply photosensitizing drugs specifically to tumor tissue using the principles of polyphasic tumor therapies is outlined. Key compounds are tumor specific functionalized antibodies with reduced immunogenicity. These bind to drug inclusion complexes in a multiplicative manner. Drug inclusion complexes are designed on the basis of tethered functionalized (beta) -cyclodextrin dimers with maximum affinity to porphyrinoid photosensitizers forming monomeric chlathrates. To enhance porphyrin-cyclodextrin interaction peripheral groups of the porphyrin have to be chemically modified. The development of the method is not yet completed. First results are demonstrated.

Citation Download Citation

Joerg G. Moser, Anja Ruebner-Heuermann, Peter Oehr, Hugo Scheer, Anja Vervoorts, and Sonja Andrees "Carrier systems in PDT: on the way to novel antitumor drugs", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199131

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