Comparative in vitro and in vivo measurements of hydrophilic and hydrophobic porphyrins

Herbert Schneckenburger; Reinhard Sailer; Michael H. Gschwend; Karin Kunzi-Rapp; Angelika C. Rueck; Wolfgang S. L. Strauss

doi:10.1117/12.199133

12 January 1995 Comparative in vitro and in vivo measurements of hydrophilic and hydrophobic porphyrins

Herbert Schneckenburger, Reinhard Sailer, Michael H. Gschwend, Karin Kunzi-Rapp, Angelika C. Rueck, Wolfgang S. L. Strauss

Author Affiliations +

Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199133
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

The photosensitizers uroporphyrin III (UP III), coproporphyrin III (CP III), and protoporphyrin IX (PP IX) were examined with respect to their composition (by different molecular species), uptake and distribution in cells and tissues, intracellular pH value, cytotoxicity and formation of photoproducts. Whereas hydrophilic UP III and CP III were characterized by low cytotoxicity and preferential accumulation in lysosomes, hydrophobic PP IX was found to be rather cytotoxic and mainly localized in cellular membranes. Rapid uptake in tissues and some preferential location in tumor cells were detected for hydrophobic photosensitizers.

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Herbert Schneckenburger, Reinhard Sailer, Michael H. Gschwend, Karin Kunzi-Rapp, Angelika C. Rueck, and Wolfgang S. L. Strauss "Comparative in vitro and in vivo measurements of hydrophilic and hydrophobic porphyrins", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199133

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