12 January 1995 Discrepancy between photodynamic injuries and pheophorbide A accumulation in digestive tissues
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Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199146
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France
This report describes the discrepancy between pheophorbide A (PH-A) localization and photodynamically induced necrosis for the digestive tract. After an IV 9 mg/Kg-1 sensitization, the dye was caught by the whole digestive tract and its inherent vessels, as shown by fluorescence microscopy. The dye fluorescence disappeared within 24 h from the stomach and the jejunum. It remained high in the pancreas, the portal vein, the bile duct, the arteries and the duodenal mucosae. A light dose, 660 nm, 100 J/cm-2, 24 h after Ph-A sensitization, induced a necrosis of the duodenal mucosae. The pancreas and the hepatic pedicle were relatively unaffected by photodynamic therapy (PDT). The duodenal response to PDT results logically from its selective PH-A retention. But hepatic pedicule and pancreas immunities for PDT involve either protecting singlet oxygen scavengers or photosensitizer quenchers.
© (1995) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
S. Evrard, M. Koenig, C. Damge, Jacques Marescaux, M. Aprahamian, "Discrepancy between photodynamic injuries and pheophorbide A accumulation in digestive tissues", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199146; https://doi.org/10.1117/12.199146

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