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12 January 1995 Experimental studies of combination of PDT and tumor chemotherapy or 60Co irradiation
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Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199172
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France
Abstract
We present experimental results obtained by combining photodynamic therapy (PDT) with tumor chemotherapy or radiotherapy. Dimethoxyhematoporphyrin (DMHp) and photosan (PS) were used as photosensitizers, pharanoxi and vincristine as antitumor drugs. The therapeutic effect of the combination of PDT and antitumor drugs (pharanoxi, vincristine) slightly increases as compared to the treatment of PDT or antitumor drug alone. The additive therapeutic effect is achieved under the combination of PDT and 60Co irradiation. It seems that the sensitizers DMHp and PS regulate lipid peroxidation in blood serum of experimental animals, which becomes more active under the influence of alkylating antitumor drugs. Therefore, they could protect an organism from negative influence of tumor chemotherapy.
© (1995) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Janina Didziapetriene, Grazina Prasmickiene, Dalija Sukeliene, Ricardas Rotomskis, Giedre Streckyte, Vydmantas Atkocius, Laima Staciokiene, and Valerijus Smilgevicius "Experimental studies of combination of PDT and tumor chemotherapy or 60Co irradiation", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199172
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