In vitro photobiological activity of a new series of photosensitizers: the glycoconjugated porphyrins

Michel Momenteau; Dalila Oulmi; Philiippe Maillard; Alain F. Croisy

doi:10.1117/12.199141

12 January 1995 In vitro photobiological activity of a new series of photosensitizers: the glycoconjugated porphyrins

Michel Momenteau, Dalila Oulmi, Philiippe Maillard, Alain F. Croisy

Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199141
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

The in vitro photodynamic inactivation of a KB cell line is studied using a large series of neutral water-soluble glycosylated porphyrins. These compounds in which hydrophilic glycosyl moieties and hydrophobic substituents are linked at the meso positions, generate singlet oxygen in roughly 70%. Results reveal that the phototoxicity is markedly dependent on the nature, the number, and the linking position of glycosyl moieties controlling their amphiphilic characters.

Citation Download Citation

Michel Momenteau, Dalila Oulmi, Philiippe Maillard, and Alain F. Croisy "In vitro photobiological activity of a new series of photosensitizers: the glycoconjugated porphyrins", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199141

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