12 January 1995 Selective synthesis and photophysical properties of tailor-made chlorins for photodynamic therapy
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Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199155
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France
Abstract
Photodynamic therapy (PDT) is a promising approach for the treatment of cancer, and is presently being evaluated worldwide. PDT is based on the ability of photosensitizers to accumulate selectively in tumor tissue. On irradiation fluorescence of the sensitizer allows tumor localization. Singlet oxygen formed by sensitization causes tumor destruction. Hematoporphyrin derivatives and Photofrin IIR, at the present the only practically used sensitizers in PDT, absorb light only weakly ((epsilon) approximately equals 5.000 at (lambda) equals 620 nm). It has been shown that Photofrin IIR is a multicomponent mixture of different porphyrins with only a few therapeutically active components. In contrast to porphyrins, chlorins and azachlorins have ideal photophysical properties with strong absorption ((epsilon) approximately equals 50.000) in a spectral region ((lambda) equals 650 nm) where tissue transmits much better. Molecular properties of porphinoid structures, which are responsible for tumor uptake and tumor enrichment, are connected with lipophilicity and aggregation behavior. Therefore our aim was to synthesize well defined chlorins with lipophilic properties similar to those of the active fractions of Photofrin IIR.
© (1995) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Franz-Peter Montforts, Franz-Peter Montforts, Benjamin Gerlach, Benjamin Gerlach, Gerold Haake, Gerold Haake, Frank Hoeper, Frank Hoeper, Dirk Kusch, Dirk Kusch, Axel Meier, Axel Meier, Gerhard Scheurich, Gerhard Scheurich, Hans-Dieter Brauer, Hans-Dieter Brauer, K. Schiwon, K. Schiwon, Guido Schermann, Guido Schermann, } "Selective synthesis and photophysical properties of tailor-made chlorins for photodynamic therapy", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199155; https://doi.org/10.1117/12.199155
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