Synthesis and properties of ether-bonded porphyrin-chlorin dimers

Andrei F. Mironov; Ekaterina G. Levinson

doi:10.1117/12.199161

12 January 1995 Synthesis and properties of ether-bonded porphyrin-chlorin dimers

Andrei F. Mironov, Ekaterina G. Levinson

Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199161
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

Synthesis of a series of model ether-bonded porphyrin-chlorin dimers with graded amphiphility as advantageous sensitizers for photodynamic therapy has been performed. Two macrocycles have been condensed via porphyrin-o1 trifluoroacetate. Hydroxyoctaethylporphyrin has been chosen as hydrophobic moiety and purpurin 18 derivatives have been chosen as hydrophilic components. New dimers have intense absorption maxima in the range of 665 - 700 nm, as well as weaker peaks at 622 - 624 nm that allows us to work with these sensitizers following new laser techniques which permit deeper light penetration into the tissues. The presence of hydrophobic octaethylporphyrin moiety and hydrophilic tri-carboxychlorin part in one molecule allows us to select structure with optimal amphiphility for sensitizer penetration and accumulation.

Citation Download Citation

Andrei F. Mironov and Ekaterina G. Levinson "Synthesis and properties of ether-bonded porphyrin-chlorin dimers", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199161

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