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31 January 1995 Influence of multiple scattering effects on in vivo NIR spectroscopy
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Proceedings Volume 2326, Photon Transport in Highly Scattering Tissue; (1995)
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France
On the basis of both homogeneous and layered skin models this paper analyzes the influences of multiple scattering of skin on the measurements of NIR spectroscopy. Emphasis is laid on the wavelengths of 660, 805, and 940 nm which are used in clinical monitoring systems. The results of Monte-Carlo simulation show that the overwhelming scattering of tissue leads to a nonlinearity in the Lambert-Beer's relation between optical density and chromophore concentration. The consequences of this effect shall be discussed using as an example the non invasive measurement of Indocyanine Green (ICG) in the blood. In this case the multiple scattering of skin causes substantial non-linear relation between the optical density at 805 nm and the concentration of an injected NIR dye in the blood if the concentration of ICG exceeds 10 mg/l. This leads to a significant distortion of the ICG clearance curve and in consequence to a systematic error in the determination of physiological parameters. For multi-wavelength spectroscopy the wavelength dependency of scattering coefficients has to be noticed. The consequence of this effect is demonstrated for blood oxygen saturation (SaO2) measurements.
© (1995) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Chongwu Du and Werner Nahm "Influence of multiple scattering effects on in vivo NIR spectroscopy", Proc. SPIE 2326, Photon Transport in Highly Scattering Tissue, (31 January 1995);

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