Optical imaging via biological object internal structure contrasting

Vitaly M. Podgaetsky; Sergei A. Tereshchenko; Nikolai S. Vorobiev; Larisa G. Tomilova; Alexander V. Smirnov; Andrei V. Ivanov

doi:10.1117/12.200816

31 January 1995 Optical imaging via biological object internal structure contrasting

Vitaly M. Podgaetsky, Sergei A. Tereshchenko, Nikolai S. Vorobiev, Larisa G. Tomilova, Alexander V. Smirnov, Andrei V. Ivanov

Author Affiliations +

Proceedings Volume 2326, Photon Transport in Highly Scattering Tissue; (1995) https://doi.org/10.1117/12.200816
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

For successful application of laser tomography methods for earlier medical diagnostics the signal-to-noise ratio (contrast) must be increased. For this purpose it is possible to use the absorbing dyes. We have theoretically investigated optical imaging conditions in high scattering medium on a model object. In our experiments a YAG:Nd laser generating picosecond pulses was employed. Output radiation has been recorded by a high speed streak camera with 1.5 ps temporal resolution. The high stability of the laser and of measurement scheme characteristics was provided. We looked for the contrasting substances having tropism with pathologically changed tissue of the tumor. For this purpose some dyphthalocyanines were synthesized. The experiments with laboratory animals have demonstrated that saturated dye concentrations were noticeably lower than toxicologic dangerous concentration values. We have demonstrated a possibility of the contrasting for a model object. The experimental temporal profile of scattered radiation can be explained by the nonstationary two-flow theory.

Citation Download Citation

Vitaly M. Podgaetsky, Sergei A. Tereshchenko, Nikolai S. Vorobiev, Larisa G. Tomilova, Alexander V. Smirnov, and Andrei V. Ivanov "Optical imaging via biological object internal structure contrasting", Proc. SPIE 2326, Photon Transport in Highly Scattering Tissue, (31 January 1995); https://doi.org/10.1117/12.200816

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
9 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Scattering

Laser scattering

Optical imaging

Photons

Absorption

Picosecond phenomena

X-ray computed tomography

Show All Keywords

Keywords/Phrases

Search In:

Publication Years