Diode laser and interstitial hyperthermia against HT29 colonic cancer: effect of power settings on secrosis size

Michel Prudhomme M.D.; Jing Tang; Simone Rouy; Guy P. Delacretaz; Rene-Paul Salathe; Guilhem Godlewski M.D.

doi:10.1117/12.197574

23 December 1994 Diode laser and interstitial hyperthermia against HT29 colonic cancer: effect of power settings on necrosis size

Michel Prudhomme M.D., Jing Tang, Simone Rouy, Guy P. Delacretaz, Rene-Paul Salathe, Guilhem Godlewski M.D.

Author Affiliations +

Proceedings Volume 2327, Medical Applications of Lasers II; (1994) https://doi.org/10.1117/12.197574
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

An experimental procedure of antitumoral interstitial diode laser hyperthermia was achieved in a series of 30 Swiss nu/nu mice (10 weeks old, 25 g weight). The tumor model was a subcutaneous HT29 colonic carcinoma. The diode laser (830 nm) was applied through a 300 micrometers optic fiber implanted in the tumor and delivered at different powers as follow: group 1 -- 0.2 W (n equals 5); group 2 -- 0.5 W (n equals 4); group 3 -- 0.8 W (n equals 4); group 4 -- 1.0 W (n equals 4); group 5 -- 1.2 W (n equals 4); group 6 -- 1.5 W (n equals 4); group 7 -- 1.8 W (n equals 5). The exposure time was 900 sec (360 to 1 620 J). According to the different laser applications the temperature range was 48.2 degree(s)C to 73.7 degree(s)C in the center of the tumor and 42.0 degree(s)C to 63.5 degree(s)C in its peripheral part. The tumor was removed 24 h after laser treatment. The largest necrosis diameter evaluated by macroscopic and histological sections were 8, 11, 13.25, 17.65, 18, 18.25 and 18.5 mm in the group 1, 2, 3, 4, 5, 6, 7, respectively. In the groups 6 and 7 (1.5 and 1.8 W) all animals died after treatment, the death being explained by extensive hyperthermia. Our results suggest that 1.0 W/900 sec might be the most effective condition for treating this tumor model in Swiss nu/nu mice.

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Michel Prudhomme M.D., Jing Tang, Simone Rouy, Guy P. Delacretaz, Rene-Paul Salathe, and Guilhem Godlewski M.D. "Diode laser and interstitial hyperthermia against HT29 colonic cancer: effect of power settings on necrosis size", Proc. SPIE 2327, Medical Applications of Lasers II, (23 December 1994); https://doi.org/10.1117/12.197574

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