Histology of overlapping and nonoverlapping pulsed-dye-laser pulses on normal human skin

Petra H. L. Koster; Allard C. van der Wal; Chantal M.A.M. van der Horst

doi:10.1117/12.197589

23 December 1994 Histology of overlapping and nonoverlapping pulsed-dye-laser pulses on normal human skin

Petra H. L. Koster, Allard C. van der Wal, Chantal M.A.M. van der Horst

Proceedings Volume 2327, Medical Applications of Lasers II; (1994) https://doi.org/10.1117/12.197589
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

In treatment of port-wine stains with a pulsed dye laser, whether to deliver the pulses with or without overlap remains controversial. Therefore the effect of overlap on vascular damage was histologically objectivated by taking biopsies from normal human skin of 5 healthy volunteers, who had laser pulses delivered as follows: 1 single pulse, 2 completely overlapping pulses, 2 pulses with approximately 30% overlap, and 2 pulses with 1 - 2 mm normal skin in between. For these experiments a Candela SPTL-1 with a wavelength of 585 nm was used to deliver 5 mm diameter pulses at an energy level of 7.0 J/cm². Light microscopy of the biopsies taken 24 hours after delivering the pulses shows that in overlapping pulses the inflicted damage still seems to be confined to the vessels, but that it extends deeper into the dermis. A striking observation, however, is that concerning the depth of vessel damage, even in non- overlapping pulses, the adjoining pulses have an invigorating effect on each other.

Citation Download Citation

Petra H. L. Koster, Allard C. van der Wal, and Chantal M.A.M. van der Horst "Histology of overlapping and nonoverlapping pulsed-dye-laser pulses on normal human skin", Proc. SPIE 2327, Medical Applications of Lasers II, (23 December 1994); https://doi.org/10.1117/12.197589

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