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22 December 1994 In vivo optical coherence tomography of human skin microstructure
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Proceedings Volume 2328, Biomedical Optoelectronic Devices and Systems II; (1994)
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France
A compact effective optical coherence tomography (OCT) system is presented. It contains approximately equals 0.3 mW superluminescent diode with spectral width 30 nm FWHM (providing approximately equals 15 micrometers longitudinal resolution) and fiber interferometer with integrated longitudinal scanning. The dynamic range 60 dB allows to observe structure of human skin in vivo up to 1.5 mm in depth. A comparison of obtained tomographs with data of histologic analysis of the same samples of the skin have been carried out to identify the observed structures and determine their optical properties. This technique allows one to perform noncontact, noninvasive diagnostic of early stages of different pathological state of the skin, to measure the burn depth and to observe the process of the recovery. Unlike scanning confocal microscopy, OCT is more suitable for an endoscopic investigation of the mucous membranes of hollow organs. Possible diagnostic applications include dermatology, gastroenterology, gynecology, urology, oncology, othorinolaryngology, transplantology. The most promising features are the potential possibility of differential diagnosis of precancer and various types of cancer, estimation of the invasion depth, differential diagnosis of inflammation and dystrophic processes, control of radical operative treatment.
© (1994) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Alexander M. Sergeev, Valentin M. Gelikonov, Grigory V. Gelikonov, Felix I. Feldchtein, Kirill I. Pravdenko, Dmitry V. Shabanov, Natalia D. Gladkova, Vitaly Pochinko, V. Zhegalov, G. Dmitriev, I. Vazina, Galina P. Petrova, and Nikolai K. Nikulin "In vivo optical coherence tomography of human skin microstructure", Proc. SPIE 2328, Biomedical Optoelectronic Devices and Systems II, (22 December 1994);

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