1 February 1995 Ultrastructural evaluation of CaD2 mouse mammary carcinoma after photodynamic therapy with meso-tetra(hydroxyphenyl)porphyrin (m-THPP) or its corresponding chlorin (m-THPC)
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Proceedings Volume 2329, Optical and Imaging Techniques in Biomedicine; (1995) https://doi.org/10.1117/12.200905
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France
Abstract
The ultrastructural changes that occurred in CaD2 mouse mammary carcinoma at 1, 24, and 96 h after photodynamic therapy (PDT) with meso-tetra(m-hydroxyphenyl)porphyrin (m- THPP, 5 mg/kg b.w.) or its corresponding chlorin (m-THPC, 1 mg/kg b.w.) were investigated. The destruction of the tumors occurred at a faster rate and was more severe by m-THPC-PDT than m-THPP-PDT, although the dose of m-THPC used was 5 times lower than that of m-THPP. The ultrastructral alterations of the tumors after PDT with m-THPP or m-THPC were qualitatively similar: direct damage to both microvasculature and neoplastic cells of the tumors.
© (1995) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Qian Peng, Johan Moan, Jahn M. Nesland, "Ultrastructural evaluation of CaD2 mouse mammary carcinoma after photodynamic therapy with meso-tetra(hydroxyphenyl)porphyrin (m-THPP) or its corresponding chlorin (m-THPC)", Proc. SPIE 2329, Optical and Imaging Techniques in Biomedicine, (1 February 1995); doi: 10.1117/12.200905; https://doi.org/10.1117/12.200905
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