2 January 1995 Dependences of erythrocytes aggregation and disaggregation parameters on suspension hematocrit: study by backscattering nephelometry
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Proceedings Volume 2370, 5th International Conference on Laser Applications in Life Sciences; (1995); doi: 10.1117/12.197470
Event: Laser Applications in Life Sciences: 5th International Conference, 1994, Minsk, Belarus
Abstract
The backscattering nephelometry technique is used to simultaneously obtain the aggregation and disaggregation parameters of erythrocytes in whole blood: characteristic times T1 of linear aggregates formation and T2 of network formation; hydrodynamic durability of aggregates (beta) , and the coefficient of deformability of erythrocytes D. We have previously shown that these parameters are sensitive to different diseases, external conditions and stimuli. Samples of blood have different values of hematocrit H. So we have studied dependences of parameters T1, T2, and (beta) on suspension hematocrit. The obtained results show that the values of T1 are inversely proportional to H2 for both blood of healthy donors and blood of patients suffering hereditary glomerulonephritis. With hematocrit growing towards 100% (H equals 1) these aggregation parameters asymptotically aspire to certain values which determine the natural limit of the aggregation rate. The decrease of hematocrit causes the intensification of shear-induced aggregation at shear rates up to 150 s-1.
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Nikolai N. Firsov, Alexander V. Priezzhev, Olga M. Ryaboshapka, Igor V. Sirko, Marina G. Vyshlova, "Dependences of erythrocytes aggregation and disaggregation parameters on suspension hematocrit: study by backscattering nephelometry", Proc. SPIE 2370, 5th International Conference on Laser Applications in Life Sciences, (2 January 1995); doi: 10.1117/12.197470; https://doi.org/10.1117/12.197470
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KEYWORDS
Blood

Backscatter

Plasma

Life sciences

Laser applications

Light scattering

Solids

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