2 January 1995 Regulation of photosensitizing activity of chlorin e6 derivatives in biosystems
Author Affiliations +
Proceedings Volume 2370, 5th International Conference on Laser Applications in Life Sciences; (1995) https://doi.org/10.1117/12.197443
Event: Laser Applications in Life Sciences: 5th International Conference, 1994, Minsk, Belarus
Abstract
The mechanisms of cellular uptake of the photosensitizers chlorin e6, chlorin e6 trimethylester and chlorin e6 ethylendiamid are reported in this paper. Each photosensitizer cellular uptake mechanism was determined by preferentially inhibiting the process of low-density lipoprotein (LDL) binding to cells and endocytosis by chilling cellular cultures or by the action of metabolic inhibitors or heparin. The results indicate that delivery with LDL plays a significant role in the process of pigment accumulation by tumor cells. At the same time chlorin e6 derivatives uptake is only partly mediated by receptor dependence endocytosis of LDL. The involvement of molecular diffusion exchange into the binding of apolar chlorin e6 derivatives to cells is suggested.
© (1995) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
S. N. Charankevich, Vladimir P. Zorin, Tatyana E. Zorina, Ivan I. Khludeyev, Iosif S. Mikhalovsky, "Regulation of photosensitizing activity of chlorin e6 derivatives in biosystems", Proc. SPIE 2370, 5th International Conference on Laser Applications in Life Sciences, (2 January 1995); doi: 10.1117/12.197443; https://doi.org/10.1117/12.197443
PROCEEDINGS
5 PAGES


SHARE
Back to Top