Enhanced photodynamic therapy and dosimetry by light-induced fluorescence

Daniel Braichotte; Jean-Francois Savary; Philippe Monnier; Hubert van den Bergh

doi:10.1117/12.203436

1 March 1995 Enhanced photodynamic therapy and dosimetry by light-induced fluorescence

Daniel Braichotte, Jean-Francois Savary, Philippe Monnier, Hubert van den Bergh

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203436
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

For a given light and photosensitizer dose the degree of reaction of a tissue after photodynamic therapy (PDT) with tetra(meta-hydroxyphenyl)chlorin (mTHPC) shows large differences from one patient to another. This can be explained by variation of the photosensitizer (PS) concentration in the tissue of interest and can lead to undertreatment of the lesion and overtreatment of the surrounding normal tissue. A better prediction of the degree of reaction can be obtained by taking into account the drug concentration measured by light induced fluorescence (LIF) and by adjusting the light dose consequently.

Citation Download Citation

Daniel Braichotte, Jean-Francois Savary, Philippe Monnier, and Hubert van den Bergh "Enhanced photodynamic therapy and dosimetry by light-induced fluorescence", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203436

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