New light source for PDT of skin lesions

Rolf-Markus Szeimies; Sigrid Karrer; Alfred Heine; Wolfgang Baeumler; Michael Landthaler

doi:10.1117/12.203376

1 March 1995 New light source for PDT of skin lesions

Rolf-Markus Szeimies, Sigrid Karrer, Alfred Heine, Wolfgang Baeumler, Michael Landthaler

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203376
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

Since coherence of laser light is not necessary for PDT of skin tumors, attempts have been made to construct incoherent lamps. A recent development is PDT 1200 (Waldmann Medizintechnik/FRG), a light source based on a 1200 watt metal halogen lamp. Emission of 580 to 740 nm radiation is achieved by using cut off filters. Power density can be varied from 30 mW/cm² to 200 mW/cm² in an area from 100 to 300 cm². Biologic effectiveness was proved by comparison with the radiation of an argon-pumped dye laser emitting light at 630 nm. Three human cell lines were incubated with photofrin (5 (mu) g/ml and 10 (mu) g/ml) for 24 hours. After irradiation a MTT-test was performed to assess cell viability. Results clearly proved biological effectiveness of the light source PDT 1200. No significant difference in cell viability was detected using either concentration of sensitizer. Therefore, we believe that PDT 1200 is a promising new light source for photodynamic therapy of skin lesion.

Citation Download Citation

Rolf-Markus Szeimies, Sigrid Karrer, Alfred Heine, Wolfgang Baeumler, and Michael Landthaler "New light source for PDT of skin lesions", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203376

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