1 March 1995 Photodynamic therapy induced leukocyte adherence in normal subcutaneous, but not in tumor microvessels
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Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203393
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States
Abstract
Leukocyte mediated tissue damage is proposed to contribute to the tumoricidal effect of photodynamic therapy (PDT). To elucidate this hypothesis leukocyte-endothelium interaction and red blood cell velocity in the microvasculature of an amelanotic melanoma and normal tissue in a skin fold chamber preparation were investigated before and after PDT (5 mg/kg PhotofrinR; 630 nm; 10 or 100 J/cm2). One hour after PDT (10 and 100 J/cm2) the number of adhering leukocytes increased in subcutaneous but not in tumor microvessels. At this time red blood cell velocity remained unaltered in microvessels of subcutaneous tissue but decreased (10 J/cm2) and even ceased (100 J/cm2) in tumor microvessels. These results indicate that tumor destruction induced by PDT is not mediated by leukocyte-endothelium interaction.
© (1995) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Marc Dellian, Marc Dellian, Christoph Abels, Christoph Abels, Gerhard E.H. Kuhnle, Gerhard E.H. Kuhnle, Alwin E. Goetz, Alwin E. Goetz, "Photodynamic therapy induced leukocyte adherence in normal subcutaneous, but not in tumor microvessels", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203393; https://doi.org/10.1117/12.203393
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