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1 March 1995 Significance of threshold doses for photodynamic therapy of melanotic and amelanotic tumors
Joerg G. Moser, R. Suchomski, Till Danielowski, Birgit Wagner, H. Scheer, G. Hartwich
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Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203446
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States
Abstract
The decay of the surviving cell fraction, F, during photodynamic treatment of a cell population, F0, vs. energy dose obeys an exponential law. The integrated logarithmic form yields a straight line with intercept 0 and slope -k. The reciprocal slope yields LD90, i.e., the energy fluence (J/cm2) necessary to kill 90% of the cell population F0. In reality there are deviations from this simple set of equations. At low power densities most photosensitizers are unable to kill cells. This leads to an `optical threshold' without cell destruction but frequently with cell stimulating effects, so called `overshots.' This general phenomenon occurs in a very pronounced form with melanotic melanoma cells.
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Joerg G. Moser, R. Suchomski, Till Danielowski, Birgit Wagner, H. Scheer, and G. Hartwich "Significance of threshold doses for photodynamic therapy of melanotic and amelanotic tumors", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203446
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KEYWORDS
Photodynamic therapy
Tumors
Melanoma
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