30 May 1995 Glucose-induced changes in scattering and light transport in tissue-simulating phantoms
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Abstract
The presence of glucose in an aqueous solution increases its refractive index and therefore has an influence upon the scattering properties of particles suspended in solution. The subsequent effect upon light transport in multiple scattering, tissue simulating phantoms is demonstrated experimentally in a slab geometry and theoretically by applying diffusion theory. As the glucose-induced scattering changes are small, any possible application for noninvasive glucose monitoring in diabetic parients has to rely on an accurate separation of scattering and absorption changes. In phangom studies, it is shown that optional measurements in the frequency domain allow this separation. Furthermore, preliminary experiments suggest that this method can be applied in vivo. It was found that changing the blood flow in tissue, the effect on the scattering coefficient is small.
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Matthias Kohl-Bareis, Matthias Essenpreis, Dirk Boecker, Mark Cope, "Glucose-induced changes in scattering and light transport in tissue-simulating phantoms", Proc. SPIE 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation, (30 May 1995); doi: 10.1117/12.209947; https://doi.org/10.1117/12.209947
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