Molecular mechanism of biological and therapeutical effect of low-intensity laser irradiation

Vasili A. Mostovnikov; Galina R. Mostovnikova; Vitali Yu Plavski; Ljudmila G. Plavskaja; Raisa P. Morozova

doi:10.1117/12.209927

22 May 1995 Molecular mechanism of biological and therapeutical effect of low-intensity laser irradiation

Vasili A. Mostovnikov, Galina R. Mostovnikova, Vitali Yu Plavski, Ljudmila G. Plavskaja, Raisa P. Morozova

Proceedings Volume 2391, Laser-Tissue Interaction VI; (1995) https://doi.org/10.1117/12.209927
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

The investigations carried out in our group on biological systems of various organization level (enzyme molecules in solution, human and animal cell cultures), allowed us to conclude, that the light-induced changes of spatial structure of cells components form the basis of biological activity (and as a consequence therapeutic effect) of various wavelength low-intensity laser emission. Photophysical mechanism of these changes lies in the reorientation of highregulated anisotropic parts (domains) with the liquid-crystalline type of ordering of the cell components due to the interaction between the electric field and the light induced integral electric dipole of the domain. The mechanism of such reorientation is well established in physics of liquid crystals of nematic type and is known as light induced analogue of Frederix's effect. The following results enable us to draw the conclusion about the determining role of the orientations effects on the biological activity mechanism of low-intensity laser radiation: (i) the possibility of reversible modification of spatial structure and enzyme molecules functional activity under the influence of laser radiation outside the band of their own or admixture absorption; (ii) the dependence of biological effect of laser radiation on the functional activity of cells vs. polarization degree of the light with the maximum photobiological effects observed for linear-polarized radiation; (iii) the equivalence of a static magnetic field and low-intensity laser radiation in action on functional activity of the cells and the lowering of the laser field intensity for the achieving the difinite changes of the cell functional activity in the presence of static magnetic field.

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Vasili A. Mostovnikov, Galina R. Mostovnikova, Vitali Yu Plavski, Ljudmila G. Plavskaja, and Raisa P. Morozova "Molecular mechanism of biological and therapeutical effect of low-intensity laser irradiation", Proc. SPIE 2391, Laser-Tissue Interaction VI, (22 May 1995); https://doi.org/10.1117/12.209927

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