12 May 1995 Optothermal skin hydration measurement in the presence of topically applied substances
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Abstract
Although the direct measurement of in-vivo stratum corneum hydration is relatively straightforward using the technique of opto-thermal transient emission radiometry, assessing the effect of a topically applied substance can be complex. The substance itself may change over time and may also contribute to the measured opto-thermal signal. The method developed to account for these changes uses concurrent in-vivo and in-vitro measurements. It is illustrated with topically applied petroleum jelly, dimethyl sulphoxide (DMSO) and an anti- perspirant. The petroleum jelly caused an increase in stratum corneum hydration, whilst DMSO caused a decrease, which recovers over 90 minutes. The anti-perspirant was applied before exercising and, whilst an untreated site became more hydrated, the treated site was found to become drier.
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Ravindar M.S. Bindra, Ravindar M.S. Bindra, Robert E. Imhof, Robert E. Imhof, P. Xiao, P. Xiao, Jeremy J. Andrews, Jeremy J. Andrews, "Optothermal skin hydration measurement in the presence of topically applied substances", Proc. SPIE 2395, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V, (12 May 1995); doi: 10.1117/12.209144; https://doi.org/10.1117/12.209144
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