Photodynamic therapy as an adjuvant intraoperative treatment of recurrent head and neck carcinomas

Merrill A. Biel M.D.

doi:10.1117/12.209106

12 May 1995 Photodynamic therapy as an adjuvant intraoperative treatment of recurrent head and neck carcinomas

Merrill A. Biel M.D.

Proceedings Volume 2395, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V; (1995) https://doi.org/10.1117/12.209106
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

Despite aggressive surgical and radiotherapy, recurrence rates for patients with recurrent head and neck carcinomas remain high. Photodynamic therapy has been successfully used to treat patients with early carcinomas. This is due to the ability of the activating laser light to penetrate up to one centimeter into tissue, resulting in destruction of microscopic tumor with preservation of normal tissues. Employing this principle, PDT was used as an adjuvant intraoperative therapy following resection of tumor in five patients with recurrent infiltrating carcinomas of the head and neck. All patients tolerated the treatment without complications and all but one remains free of disease twenty-four months post-treatment. Adjuvant intraoperative PDT may improve cure rates of recurrent head and neck malignancies by providing for larger tumor-free margins of resection while preserving normal structures.

Citation Download Citation

Merrill A. Biel M.D. "Photodynamic therapy as an adjuvant intraoperative treatment of recurrent head and neck carcinomas", Proc. SPIE 2395, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V, (12 May 1995); https://doi.org/10.1117/12.209106

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