12 May 1995 Ultrathin angioscopic guidewire: preliminary in-vitro results
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One significant avenue for cost containment in medical care is the application of affordable spin-off technology. Innovative methods for the efficient prevention and treatment of atherosclerotic plaques in cardiac arteries will have significant implications for reducing health care costs in a large patient population. We report on preliminary work aimed at exploiting advanced sensing, fiber optic and materials technologies to create an innovative medical instrument: the Ultrathin Angioscopic Guidewire (UAG). The UAG uses an innovative method to combine high resolution fiber optic imaging bundles with flexible guidewire extensions into a integral unit having a diameter of less than 350 microns. The UAG would serve as the guidewire over a integral unit having a diameter of less than 350 microns. The UAG would serve as the guidewire over which the treatment catheter would ride eliminating repeated removal and reinsertion of the catheter for evaluation. The resulting images are coupled to a high resolution, image intensified detector. Use of digital image capture before and after treatment combined with frame processing allows for a quantitative evaluation of lesion removal and archival data to establish treatment efficacy. Once developed, this instrument will be particularly useful in conjunction with current interventional procedures. As a diagnostic tool, the intensifier in the UAG allows for sensitive imaging for application to in vivo bio/chemiluminescent immunoassays. We will present design details and discuss proof of principle results with the first prototype UAG.
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James Castracane, James Castracane, Michelle D. Conerty, Michelle D. Conerty, Warren Breisblatt, Warren Breisblatt, } "Ultrathin angioscopic guidewire: preliminary in-vitro results", Proc. SPIE 2395, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V, (12 May 1995); doi: 10.1117/12.209128; https://doi.org/10.1117/12.209128

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