Comparison of kinetic models for data from a positron emission tomograph

Pamela G. Coxson; Ronald H. Huesman; Sophanie Lim; Gregory J. Klein; Bryan W. Reutter; Thomas F. Budinger

doi:10.1117/12.209695

24 May 1995 Comparison of kinetic models for data from a positron emission tomograph

Pamela G. Coxson, Ronald H. Huesman, Sophanie Lim, Gregory J. Klein, Bryan W. Reutter, Thomas F. Budinger

Proceedings Volume 2433, Medical Imaging 1995: Physiology and Function from Multidimensional Images; (1995) https://doi.org/10.1117/12.209695
Event: Medical Imaging 1995, 1995, San Diego, CA, United States

Abstract

The purpose of this research was to compare a physiological model of ⁸²Rb in the myocardium with two reduced order models with regard to their ability to assess physiological parameters of diagnostic significance. A three compartment physiological model of ⁸²Rb uptake in the myocardium was used to simulate kinetic region of interest data from a positron emission tomograph (PET). Simulations were generated for eight different blood flow rates reflecting the physiological range of interest. Two reduced order models which are commonly used with myocardial PET studies were fit to the simulated data and the parameters of the reduced order models were compared with the physiological parameters. Then all three models were fit to the simulated data with noise added. Monte carlo simulations were used to evaluate and compare the diagnostic utility of the reduced order models.

Citation Download Citation

Pamela G. Coxson, Ronald H. Huesman, Sophanie Lim, Gregory J. Klein, Bryan W. Reutter, and Thomas F. Budinger "Comparison of kinetic models for data from a positron emission tomograph", Proc. SPIE 2433, Medical Imaging 1995: Physiology and Function from Multidimensional Images, (24 May 1995); https://doi.org/10.1117/12.209695

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