Segmentation and analysis of DNA replication sites using deformable models

Raghu P. Menon; Raj S. Acharya; Jagath K. Samarabandu; Ping Chin Cheng; Ronald Berezney

doi:10.1117/12.209717

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24 May 1995 Segmentation and analysis of DNA replication sites using deformable models

Raghu P. Menon, Raj S. Acharya, Jagath K. Samarabandu, Ping Chin Cheng, Ronald Berezney

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Proceedings Volume 2433, Medical Imaging 1995: Physiology and Function from Multidimensional Images; (1995) https://doi.org/10.1117/12.209717
Event: Medical Imaging 1995, 1995, San Diego, CA, United States

Abstract

Image segmentation is an important aspect of biomedical image analysis. Here we discuss the implementation of a system for segmentation of confocal electron microscope images of DNA within from rat liver cell nuclei. Segmentation is achieved using controlled continuity splines or 'snakes' proposed by Kass, Witkin, and Teraopoulos. A snake is an energy minimizing spline guided by external constraint forces and influenced by image forces that pull it toward features such as lines and edges. They are active contour models. They lock onto nearby edges, localizing them accurately.

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Raghu P. Menon, Raj S. Acharya, Jagath K. Samarabandu, Ping Chin Cheng, and Ronald Berezney "Segmentation and analysis of DNA replication sites using deformable models", Proc. SPIE 2433, Medical Imaging 1995: Physiology and Function from Multidimensional Images, (24 May 1995); https://doi.org/10.1117/12.209717

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