The integration of modern imaging sensors (EVS sensors) makes it possible to solve the problem of a fully bordautonomous navigation and control of airborne vehicles by means of analyzing images only. In runway referenced applications, where the flight trajectory of an aircraft has to be measured, independence from ground-based sensors can be regarded as a great advantage. The calibration of radio navigation aids, such as instrument landing systems (ILS) or differential satellite navigation systems, needs high precision and stable reference measurement methods. The photogrammetric evaluation of the center of projection of a camera which is fixed to the vehicle, offers one possibility for such a reference system, that is recently developed at DLR-Braunschweig. This system automatically analyzes and interprets on-board images. By different simulations and experiments it is shown, that such a system can meet the strong requirements for runway-reference measurements of flight path trajectories, especially for the calibration of ILS.