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19 January 1996 MR-imaging controlled laser-induced thermotherapy (LITT) of liver metastases
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As a high number of metastases grow in the liver, new treatment methods have been developed. Laser-induced thermotherapy (LITT) has recently applied for a minimally invasive technique in local treatment of liver metastases. Laser light was performed using Neodymium yttrium aluminum garnet (Nd-YAG, wavelength 1064 nm) delivered through a quartz fiber optic with a diameter of 400 micrometer with diffuse light emission. Laser light is converted into heat in the target area with an ensuing coagulative necrosis, secondary degeneration and atrophy, tumor shrinkage with minimal damage to surrounding structures. The size of heated volume depends on laser power, laser irradiation time, the way it reaches the target area and optical and thermal characteristics of the treated tissue. Pilot clinical studies have demonstrated that this technique is practical for the palliation of hepatic tumors. The clinical success of the thermotherapy depends on the optimal localization of the laser applicator in the center of the lesion, an optimal 'online monitoring' of thermal changes in the treated tissue and an exact documentation of the therapy effect and the local tumor controlrate. The individual optimization of two special developed thermosensitive sequences allows an exact monitoring of the progress of LITT to the treated lesion and surrounding structures. The purpose of this paper is to describe our experimental and clinical experience with MR-guided LITT for treatment of liver metastases and follow-up evaluation in larger series.
© (1996) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Thomas J. Vogl, Petra Mueller, Martin G. Mack, W. R. Scholz, N. Weinhold, R. Hammerstingl, H. Boettcher, Carsten M. Philipp, Andre Roggan, and Roland Felix "MR-imaging controlled laser-induced thermotherapy (LITT) of liver metastases", Proc. SPIE 2623, Medical Applications of Lasers III, (19 January 1996);


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