10 January 1996 Direct measurement of fluence rate in the human brain
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Fluence rate was measured in normal and cancerous (glioma) human brain samples using a multichannel detector. Detector consisted of 8 isotrope fiber probes positioned around the central irradiating probe. Detecting probes were displaced one from other at a step 0.5 mm along the central irradiating fiber. Bare ends of detecting fibers were coupled with photodiode array. He-Ne (633 nm) or Nd:YAG (1064 nm) lasers were coupled with irradiating probe. Fluence rate was measured in each of 8 points in the depth range 5 mm. Measured mean penetration depths of 633 nm light were 0.70 mm, 0.50 mm and 0.40 mm for white matter, grey matter and glioma, respectively. For Nd:YAG laser, penetration depth was about 2.3 mm for normal tissue and glioma. Multichannel computerized detector allows to provide a small invasive real-time measurements of fluence rate in different tissues.
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Ivan S. Melnik, Tatyana V. Rusina, Nikolay A. Denisov, Sergiy M. Dets, Rudolf W. Steiner, Vladimir D. Rozumenko, "Direct measurement of fluence rate in the human brain", Proc. SPIE 2624, Laser-Tissue Interaction and Tissue Optics, (10 January 1996); doi: 10.1117/12.229565; https://doi.org/10.1117/12.229565

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