31 January 1996 Carrier systems in PDT II: accumulation strategies of biotin-avidin coupled photosensitizers developed on cultured tumor cells
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Abstract
Two possibilities to accumulate photosensitizing drugs at the surface of cultured tumor cells were exploited: biotinylation of the cell surface followed by avidin and dibiotin, and reaction with a biotinylated antibody followed by avidin and biotinylated sulfophthalocyanin. Both reactions were performed successfully. The latter leads to enhanced phototoxicity of the accumulated drug.
© (1996) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Anja Ruebner-Heuermann, Anja Ruebner-Heuermann, Joerg G. Moser, Joerg G. Moser, Alexander P. Savitzki, Alexander P. Savitzki, D. Berendij, D. Berendij, Rainer Bayer, Rainer Bayer, Birgit Wagner, Birgit Wagner, } "Carrier systems in PDT II: accumulation strategies of biotin-avidin coupled photosensitizers developed on cultured tumor cells", Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); doi: 10.1117/12.230957; https://doi.org/10.1117/12.230957
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