Enhanced antitumoral efficacy by intratumoral perfusion of activated macrophages associated with photodynamic therapy

Vasile F. Dima; Virgil V. Vasiliu; Dezideriu Laky; Paul Ionescu; Stefan V. Dima

doi:10.1117/12.230987

31 January 1996 Enhanced antitumoral efficacy by intratumoral perfusion of activated macrophages associated with photodynamic therapy

Vasile F. Dima, Virgil V. Vasiliu, Dezideriu Laky, Paul Ionescu, Stefan V. Dima

Author Affiliations +

Proceedings Volume 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities; (1996) https://doi.org/10.1117/12.230987
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

Experiments were performed on five batches of Wistar inbred rats with Walker-256 carcinosarcoma receiving photodynamic therapy (PDT), rMuIFN-gamma activated macrophages (AM(Phi) ) or associated therapy (PDT-AM(Phi) -A; PDT-AM(Phi) -B); the control batch (HBSS) consisted of animals with untreated Walker-256 tumors. The results were as follows: the sole treatment (PDT, AM(Phi) ) gave survival rates between 57.2 and 57.7% and cure rates ranging from 23.1 to 34.3%. The 'combined' therapy in multiple doses increased significantly (87.9%) the survival rate of tumor bearing rats as well as the rate of complete tumor regression (72.7%). Cell-mediated immunity test values in batches III and IV exposed to multiple doses of PDT-AM(Phi) showed higher values as compared to the values noticed in batches I - II and the control batch V, performed at 12 and 21 days post-treatment. Summing up, these results demonstrate that 'combined' photodynamic treatment and biotherapy with interferon activated macrophages stimulate cell-mediated antitumoral activity, increase survival rates and reduce incidence of Walker-256 carcinosarcoma in rat model.

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Vasile F. Dima, Virgil V. Vasiliu, Dezideriu Laky, Paul Ionescu, and Stefan V. Dima "Enhanced antitumoral efficacy by intratumoral perfusion of activated macrophages associated with photodynamic therapy", Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); https://doi.org/10.1117/12.230987

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