31 January 1996 Monofunctional phthalocyanine derivatives as potential sensitizers for PDT
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Abstract
Syntheses, singlet oxygen 1O2 quantum yields ((Phi) (Delta )) and photostability of new monofunctional, long wavelength absorbing (680 - 750 nm) porphyrazines are reported. For the coupling to biomolecules without crosslinking reactions the sensitizers contain one reactive polar sulfo, carboxy, amino, hydroxy, or pyridyloxy group. Besides, the sensitizers are substituted by lipophilic tert-butyl, tert-butylphenoxy or alkoxy groups in order to introduce an intramolecular polarity axis for better cellular uptake and to increase solubility in organic solvents.
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Dieter Wohrle, Dieter Wohrle, Andrea Weitemeyer, Andrea Weitemeyer, Abdol Khezer Sobbi, Abdol Khezer Sobbi, Ulrike Michelsen, Ulrike Michelsen, H. Kliesch, H. Kliesch, } "Monofunctional phthalocyanine derivatives as potential sensitizers for PDT", Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); doi: 10.1117/12.230956; https://doi.org/10.1117/12.230956
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