Photodynamic therapy of spread skin malignancies with scanning electron-beam-pumped semiconductor laser

Elena G. Vakoulovskaya M.D.; Gennadii A. Meerovich; Victor V. Shental M.D.; V. N. Ulasyuk; Eugeny A. Lukyanets

doi:10.1117/12.231000

31 January 1996 Photodynamic therapy of spread skin malignancies with scanning electron-beam-pumped semiconductor laser

Elena G. Vakoulovskaya M.D., Gennadii A. Meerovich, Victor V. Shental M.D., V. N. Ulasyuk, Eugeny A. Lukyanets

Proceedings Volume 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities; (1996) https://doi.org/10.1117/12.231000
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

Photodynamic therapy (PDT) using quantoscope (scanning electron-beam pumped semiconductor laser, (lambda) equals 670 plus or minus 2 nm, P equals 10 W) and Phtalocyanine Al as photosensitizer (PS) have been provided in nine patients (27 tumor sites) with spread skin malignancies (basal cell, squamous cell cancer, melanoma, metastases of breast cancer) and cancer of the lip T2 N0 M0. During PDT power density has been from 200 to 450 mW/cm², light doses ranging from 150 to 700 J/cm². We have fulfilled diagnostic of tumor after injection of PS and have controlled treatment using spectral- fluorescent video complex. In five patients (23 sites) we had complete clinical response and in four patients (4 sites) partial response after PDT. Results of our study show that use of scanning electron-beam-pumped semiconductor laser is promising in the treatment of spread skin malignancies.

Citation Download Citation

Elena G. Vakoulovskaya M.D., Gennadii A. Meerovich, Victor V. Shental M.D., V. N. Ulasyuk, and Eugeny A. Lukyanets "Photodynamic therapy of spread skin malignancies with scanning electron-beam-pumped semiconductor laser", Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); https://doi.org/10.1117/12.231000

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