Quantification of NIRS data of a blood phantom by spectral multicomponent analysis

Chongwu Du; Werner Nahm; Hartmut Gehring; Ewald Konecny

doi:10.1117/12.228657

18 December 1995 Quantification of NIRS data of a blood phantom by spectral multicomponent analysis

Chongwu Du, Werner Nahm, Hartmut Gehring, Ewald Konecny

Proceedings Volume 2626, Photon Propagation in Tissues; (1995) https://doi.org/10.1117/12.228657
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

In order to quantify the chromophore components from in vivo blood NIRS, a blood- equivalent phantom has been developed which consists of properly diluted intralipid and ICG dye. The reflection and transmission near infrared spectroscopy (NIRS) of the phantoms with different scattering backgrounds and ICG concentrations are measured and analyzed by the spectral multicomponent analysis (MCA) method to extract ICG concentration. The experimental results show that the MCA method can be used to quantify absolute ICG concentrations in scattering media if the average path lengths are known. Moreover, it was found by the experiments that both the water absorption peak at 970 nm and the ICG absorption peak at 800 nm show similar behavior during the change of the scattering background. Thus the ratio of the MCA-estimated concentration factor of ICG to water is independent of the blood-phantom scattering.

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Chongwu Du, Werner Nahm, Hartmut Gehring, and Ewald Konecny "Quantification of NIRS data of a blood phantom by spectral multicomponent analysis", Proc. SPIE 2626, Photon Propagation in Tissues, (18 December 1995); https://doi.org/10.1117/12.228657

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KEYWORDS

Blood

Scattering

Absorption

Near infrared spectroscopy

Chromophores

Plasma

In vivo imaging

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