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18 December 1995 Resolution and sensitivity limits of optical imaging in highly scattering media
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Using photon-density-waves (PDW), (multiple) objects embedded in a highly scattering medium with optical properties similar to tissue are detected. The measurements were performed with near-infra-red laser light at 675 nm which was either kept continuous-wave (cw) or amplitude modulated (AM) at 219 MHz or 650 MHz. We find that the spatial resolution of the projection image shows only slight improvements as the frequency is increased. This improvement comes at the expense of signal strength in the modulated part of the light. That is, the PDW shows a much stronger attenuation as compared to the cw light intensity. The implications of the lower signal-to-noise ratio at high modulation frequencies is that the modulated light projections are less suitable for further data processing. For a given data acquisition system, this fact cancels the advantages of the higher raw resolution of PDW as compared to cw light. Therefore, we find no clear advantage of PDW over cw light for obtaining sharper tomographic images of the diffuse media, regardless of the inverse scattering method used.
© (1995) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Dimitrios G. Papaioannou, Sel-Brian B. Colak, and Gert W. t'Hooft "Resolution and sensitivity limits of optical imaging in highly scattering media", Proc. SPIE 2626, Photon Propagation in Tissues, (18 December 1995);

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