Subcellular photodynamic action sites of sulfonated aluminum phthalocyanines in a human melanoma cell line

Qian Peng; Jahn M. Nesland; Kari Madslien; Havard E. Danielsen; Johan Moan

doi:10.1117/12.229977

15 January 1996 Subcellular photodynamic action sites of sulfonated aluminum phthalocyanines in a human melanoma cell line

Qian Peng, Jahn M. Nesland, Kari Madslien, Havard E. Danielsen, Johan Moan

Author Affiliations +

Proceedings Volume 2628, Optical and Imaging Techniques for Biomonitoring; (1996) https://doi.org/10.1117/12.229977
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

By means of scanning and transmission electron microscopy the subcellular target sites of photodynamic therapy (PDT) with derivatives of sulfonated aluminum phthalocyanine (AlPcS₁, AlPcS₂, AlPcS₃, and AlPcS₄) were studied in a human melanoma LOX cell line. It was found that PDT with AlPcS₁ or AlPcS₂ damaged mainly the biomembraneous system of the cells, such as cytoplasmic membrane, mitochondria, endoplasmic reticulum, etc., while AlPcS₃- or AlPcS₄- induced PDT largely destroyed the lysosomes. However, none of the AlPcS_ns led to nuclear damage at an early stage after PDT. The subcellular photodynamic targets of the derivatives of AlPcS_n are related to the subcellular localization pattern of the dye in the LOX cells.

Citation Download Citation

Qian Peng, Jahn M. Nesland, Kari Madslien, Havard E. Danielsen, and Johan Moan "Subcellular photodynamic action sites of sulfonated aluminum phthalocyanines in a human melanoma cell line", Proc. SPIE 2628, Optical and Imaging Techniques for Biomonitoring, (15 January 1996); https://doi.org/10.1117/12.229977

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available