10 January 1996 Foveal cone mosaic imaged in vivo by an objective high-resolution technique
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We have developed a new technique for the objective determination of the cone spacing in the living human fovea, and obtained direct measurements of the distance between cones at retinal eccentricities ranging from 0 to 1 deg. The method is similar to stellar speckle interferometry, and consists of recording a series of short-exposure images of small foveal patches, illuminated by a laser spot. Each individual image presents a speckle pattern, correlated with the topography of the cone mosaic, and contains spatial frequency information up to the diffraction limit of the optical system of the eye. The cone spacing is measured in the spatial domain, as the reciprocal of the radius of the ring present in the average power spectrum. The results obtained are in close agreement with estimates based on microscopy of excised fovea, with psychophysical measurements, and with recent results obtained with another high resolution imaging technique outside the center of the fovea.
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Susana Celestino Marcos, Susana Celestino Marcos, Rafael Fonolla Navarro, Rafael Fonolla Navarro, Pablo Artal, Pablo Artal, } "Foveal cone mosaic imaged in vivo by an objective high-resolution technique", Proc. SPIE 2632, Lasers in Ophthalmology III, (10 January 1996); doi: 10.1117/12.229572; https://doi.org/10.1117/12.229572

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