Microscopical quantification and functional simulation of pulmonary respiratory units

Andres Kriete

doi:10.1117/12.237482

10 April 1996 Microscopical quantification and functional simulation of pulmonary respiratory units

Andres Kriete

Proceedings Volume 2655, Three-Dimensional Microscopy: Image Acquisition and Processing III; (1996) https://doi.org/10.1117/12.237482
Event: Electronic Imaging: Science and Technology, 1996, San Jose, CA, United States

Abstract

A framework for a computer-guided image acquisition procedure in confocal microscopy is described, which allows a 9-fold increase of the field of view and an extended imaging in axial direction by scanning aligned thick serial sections. Using an image compositing technique, complete respiratory units (acini) of small mammalian species (rat, mouse) could be investigated at high resolution. The quantification of the composed volume includes segmentation and topological investigation. With the help of parameters measured, a computer model of the acinus is designed to prepare functional simulations. In order to study flow of air in the acini, diffusion and the oxygen uptake, a set of mass transport equations is solved iteratively. The structural dynamics of ventilatory units during inhalation and expiration is also included.

Citation Download Citation

Andres Kriete "Microscopical quantification and functional simulation of pulmonary respiratory units", Proc. SPIE 2655, Three-Dimensional Microscopy: Image Acquisition and Processing III, (10 April 1996); https://doi.org/10.1117/12.237482

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