10 April 1996 Microscopical quantification and functional simulation of pulmonary respiratory units
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Abstract
A framework for a computer-guided image acquisition procedure in confocal microscopy is described, which allows a 9-fold increase of the field of view and an extended imaging in axial direction by scanning aligned thick serial sections. Using an image compositing technique, complete respiratory units (acini) of small mammalian species (rat, mouse) could be investigated at high resolution. The quantification of the composed volume includes segmentation and topological investigation. With the help of parameters measured, a computer model of the acinus is designed to prepare functional simulations. In order to study flow of air in the acini, diffusion and the oxygen uptake, a set of mass transport equations is solved iteratively. The structural dynamics of ventilatory units during inhalation and expiration is also included.
© (1996) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Andres Kriete, Andres Kriete, } "Microscopical quantification and functional simulation of pulmonary respiratory units", Proc. SPIE 2655, Three-Dimensional Microscopy: Image Acquisition and Processing III, (10 April 1996); doi: 10.1117/12.237482; https://doi.org/10.1117/12.237482
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