Effects of benzoporphyrin derivative monoacid on balloon-injured arteries in a swine model of restenosis

G. Michael Vincent M.D.; Jolene Fox; Suzanne Johnson; Phillipe Maragon

doi:10.1117/12.239995

17 May 1996 Effects of benzoporphyrin derivative monoacid on balloon-injured arteries in a swine model of restenosis

G. Michael Vincent M.D., Jolene Fox, Suzanne Johnson, Phillipe Maragon

Proceedings Volume 2671, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI; (1996) https://doi.org/10.1117/12.239995
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

We evaluated benzoporphyrin derivative verteporfin (BPD) photodynamic therapy (PDT) and dark effect on the intima (I) and media (M) hyperplasia (H) response of swine iliac arteries to balloon dilatation (Bdil) injury. Four month old Yucatan swine received bdil at 8 ATM pressure to all four iliac arteries. Pigs were randomly assigned to groups. PDT was performed with intraluminal 690 nm, cw laser (200 milliwatts and 30 joules per cm² tissue). Six weeks later, sites were pressure fixed, and excised at autopsy. Sections from each site were evaluated for I and M thickness, injury score (1 equals normal, 4 equals worst), and smooth muscle cell (SMC) intensity and distribution. Groups were compared using the Mann-Whitney U test. Means for each parameter were determined, and group means used for statistical analysis. Conclusions: (1) Bdil produced IH and MH. (2) PDT enhanced IH. (3) 2 mg/kg BPD reduced MH and produced a favorable trend in IH and injury. (4) No differences in SMC intensity and distribution were present.

Citation Download Citation

G. Michael Vincent M.D., Jolene Fox, Suzanne Johnson, and Phillipe Maragon "Effects of benzoporphyrin derivative monoacid on balloon-injured arteries in a swine model of restenosis", Proc. SPIE 2671, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI, (17 May 1996); https://doi.org/10.1117/12.239995

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