Effect of lgiht-activated tin ethyl etiopurpurin (SnET2) on normal rabbit choriocapillaries

Gholam A. Peyman M.D.; Darius M. Moshfeghi M.D.; Andrew Moshfeghi; Bahram Khoobehi; Daniel R. Doiron; David H. Crean

doi:10.1117/12.240061

17 May 1996 Effect of light-activated tin ethyl etiopurpurin (SnET2) on normal rabbit choriocapillaries

Gholam A. Peyman M.D., Darius M. Moshfeghi M.D., Andrew Moshfeghi, Bahram Khoobehi, Daniel R. Doiron, David H. Crean

Proceedings Volume 2673, Ophthalmic Technologies VI; (1996) https://doi.org/10.1117/12.240061
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

The aim of this study was to investigate the use of photodynamic therapy (PDT) using tin ethyl etiopurpurin (SnET2) for occluding the choriocapillaris in the eyes of pigmented rabbits. Following intravenous injection of SnET2 (0.5 and 1.0 mg/kg) or lipid emulsion alone, the fundus of pigmented rabbits was irradiated within 5 - 15 minutes of photosensitizer injection using 664 nm light at a fluence of 300 mW/cm² and light doses of 5 - 20 J/cm². Fundoscopy, fluorescein angiography (FA), and histology were performed at 1, 14 and 28 days after PDT. Following PDT, closure of choriocapillaris was achieved with light doses as low as 5 J/cm² (17 seconds). Control eyes of rabbits demonstrated no effect to light irradiation at the parameters tested. PDT with SnET2 was effective in this animal model using low levels of activating light for the treatment of choriocapillaris.

Citation Download Citation

Gholam A. Peyman M.D., Darius M. Moshfeghi M.D., Andrew Moshfeghi, Bahram Khoobehi, Daniel R. Doiron, and David H. Crean "Effect of light-activated tin ethyl etiopurpurin (SnET2) on normal rabbit choriocapillaries", Proc. SPIE 2673, Ophthalmic Technologies VI, (17 May 1996); https://doi.org/10.1117/12.240061

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