2 April 1996 Functionalized benzochlorins for PDT
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Abstract
In order to evaluate structure-activity relationships in the benzochlorin ring system, a series of functionalized benzochlorins have been synthesized by modifying the sulfonic acid group of octaethylbenzochlorin sulfonic acid (OEBCS). Using very simple chemistry it has been possible to produce a large number of benzochlorins that differ only in the nature of functionality of a pendant side arm. The introduction of zinc or tin into the benzochlorin macrocycle produces the corresponding metallated benzochlorins that retain the original functionality. The synthesis and spectroscopic properties of the free base and metallobenzochlorins are discussed. Preliminary in vivo results show that different functionality causes significant differences in biological efficacy.
© (1996) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Byron C. Robinson, Byron C. Robinson, Ricardo Orbegoso, Ricardo Orbegoso, } "Functionalized benzochlorins for PDT", Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); doi: 10.1117/12.237537; https://doi.org/10.1117/12.237537
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