2 April 1996 Intra-arterial PDT and ordinary PDT in head and neck cancer
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One of the main problems which arise employing PDT is the patient's sensitization to the sunlight during a 4 - 6 week period after the i/v photosensitizers injection. Applying PDT for patients with head and neck cancer there often is the possibility to inject photosensitizer (the doses of photosensitizer used were many times smaller than in ordinary PDT) intra-arterially (i/a). This is followed by immediate tumor irradiation with laser light. The absorbed light's energy dose is the same as the dose usually used during the PDT. Since 1989 172 head and neck tumors were treated by us applying ordinary PDT and for 17 foci of oral cancer we provided intra-arterial photodynamic therapy. The result of i/a PDT was the same as in usual usage of PDT. But i/a PDT enables the usage of much smaller doses of photosensitizer. Patients need not be protected from the sunlight. I/a PDT enables us also to use effective but quickly splitting photosensitizers.
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Laima Bloznelyte-Plesniene, Laima Bloznelyte-Plesniene, Vytautas Cepulis, Vytautas Cepulis, Igor V. Ponomarev, Igor V. Ponomarev, "Intra-arterial PDT and ordinary PDT in head and neck cancer", Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); doi: 10.1117/12.237547; https://doi.org/10.1117/12.237547

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