On-line dosimetry for photodynamic therapy: part I--incident irradiance versus space irradiance for human skin

Christine J. Radasky; David H. Crean; Daniel R. Doiron

doi:10.1117/12.237523

2 April 1996 On-line dosimetry for photodynamic therapy: part I--incident irradiance versus space irradiance for human skin

Christine J. Radasky, David H. Crean, Daniel R. Doiron

Author Affiliations +

Proceedings Volume 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V; (1996) https://doi.org/10.1117/12.237523
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

One of the key components of photodynamic therapy dosimetry studies is the actual light dose delivered to the tissue at a targeted, therapeutic depth. The light dose delivered to the tissue is dependent upon the incident irradiance at the initial point of light application as well as the tissue optical properties. Since the parameters defining the light and therapeutic dose may vary between subjects and treatment sites as well as during treatment, it is advantageous to monitor the dosimetry during photodynamic therapy. The objective of this work is to develop methodologies and systems to enable on-line dosimetry. This initial study examines the relationship between incident irradiance and space irradiance for cutaneous areas in various humans. Space irradiance levels (mW/cm²) were measured on the skin surface of 30 subjects using isotropic fiber optic probes (0.8 mm) and were compared to incident irradiance levels. Space irradiance values were obtained from various anatomical locations on each subject during surface illumination (664 plus or minus 7 nm) using an incident irradiance of 100 mW/cm². The results demonstrate ratios of space irradiance: incident irradiance from 1.49 to 2.35 for all cutaneous areas. Abnormal skin features, such as scars, birthmarks, moles, freckles, etc., on the arm demonstrated ratios ranging from 1.58 to 1.84. Variances observed within and between subjects demonstrate the need for accurate dosimetry monitoring during therapy. A larger study is planned to fully characterize space irradiance variations in normal skin as well as cutaneous lesions in additional subjects.

Citation Download Citation

Christine J. Radasky, David H. Crean, and Daniel R. Doiron "On-line dosimetry for photodynamic therapy: part I--incident irradiance versus space irradiance for human skin", Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); https://doi.org/10.1117/12.237523

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
9 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Skin

Photodynamic therapy

Tissue optics

Systems modeling

Phototherapy

Scattering

Tissues

Show All Keywords

Keywords/Phrases

Search In:

Publication Years